Most prominent:
- Oto-Manguean family (170, in Mexico)
- Arawakan family (75, Honduras to Argentina)
- Tupi family (70, Paraguay to French Guyana
- Uto-Aztecan family (60, Western USA to El Salvador)
- Quechuan family (47, Andean area)
- Na-Dene family (42 from Alaska to S.W. USA)
- Algic family (33, Canada and USA)
Source: Wikipedia